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Appendices A–G – Methods, evidence and recommendations PDF

317 Pages·2015·6.67 MB·English
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NCC-WCH Version 2.0 Preterm labour and birth Appendices A - G NICE Guideline 25 Methods, evidence and recommendations November 2015, updated June 2022 Final Commissioned by the National Institute for Health and care Excellence PPTTLLBB -- AAppppeennddiicceess Error! No text of specified style in document. Disclaimer The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian. Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties. NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the Welsh Government, Scottish Government, and Northern Ireland Executive. All NICE guidance is subject to regular review and may be updated or withdrawn. Copyright @2015 National Collaborating Centre for Women’s and Children’s Health Update information In June 2022 this document was updated to redact some content that was now out of date as a result of the 2022 evidence review on the use of repeat courses of maternal corticosteroids. See the NICE website for the current recommendations at https://www.nice.org.uk/guidance/ng25. Funding Registered charity no. 213280 PTLB - Appendices Contents Appendices .......................................................................................................................... 6 Appendix A Scope ........................................................................................................ 6 Appendix B Stakeholders .......................................................................................... 19 Appendix C Declarations of interest ......................................................................... 28 Appendix D Review protocols ................................................................................... 34 D.1 Information and support ........................................................................... 34 D.2 Prophylactic vaginal progesterone and prophylactic cervical cerclage ..... 36 D.3 Diagnosing preterm prelabour rupture of membranes (P-PROM) ............. 36 D.4 Antenatal prophylactic antibiotics for women diagnosed with preterm pre-labour rupture of membranes (P-PROM) ........................................... 37 D.5 Identifying infection in women with P-PROM ............................................ 39 D.6 'Rescue' cervical cerclarge ....................................................................... 40 D.7 Diagnosing preterm labour for women with intact membranes ................. 41 D.8 Maternal corticosteroids ........................................................................... 42 D.9 Magnesium sulphate for neonatal neuroprotection ................................... 44 D.10 Tocolysis .................................................................................................. 45 D.11 Fetal monitoring ....................................................................................... 47 D.12 Mode of birth ............................................................................................ 53 D.13 Timing of cord clamping for preterm babies ............................................. 55 Appendix E Literature search strategies .................................................................. 57 E.1 Information and support ........................................................................... 57 E.2 Prophylactic vaginal progesterone ........................................................... 64 E.3 Diagnosing preterm prelabour rupture of membranes (P-PROM) ............. 65 E.4 Antenatal prophylactic antibiotics for women with P-PROM ..................... 76 E.5 Identifying infection in women with P-PROM ............................................ 86 E.6 Cerclage .................................................................................................. 99 E.7 Diagnosing preterm labour for women with intact membranes ............... 106 E.8 Maternal corticosteroids ......................................................................... 120 E.9 Magnesium sulfate for neuroprotection .................................................. 129 E.10 Tocolysis ................................................................................................ 139 E.11 Fetal monitoring ..................................................................................... 152 E.12 Mode of birth .......................................................................................... 193 E.13 Timing of cord clamping ......................................................................... 203 Appendix F PRISMA flow diagrams ........................................................................ 211 F.1 Information and support ......................................................................... 211 F.2 Prophylactic vaginal progresterone and prophylactic cervical cerclage .. 212 F.3 Diagnosis of preterm prelabour rupture of membranes (P-PROM) ......... 214 F.4 Antenatal prophylactic antibiotics for women with P-PROM ................... 215 F.5 Identifying infection in women with P-PROM .......................................... 216 4 PTLB - Appendices F.6 ‘Rescue’ cervical cerclage ...................................................................... 217 F.7 Diagnosing preterm labour for women with intact membranes ............... 218 F.8 Maternal corticosteroids ......................................................................... 219 F.9 Magnesium sulphate for neuroprotection ............................................... 221 F.10 Tocolytic drugs ....................................................................................... 222 F.11 Fetal monitoring ..................................................................................... 223 F.12 Mode of birth .......................................................................................... 228 F.13 Timing of cord clamping for preterm babies ........................................... 229 Appendix G Excluded studies ................................................................................. 230 G.1 Information and support ......................................................................... 230 G.2 Prophylactic vaginal progesterone and prophylactic cervical cerclage ... 234 G.3 Diagnosis of preterm prelabour rupture of membranes (P-PROM) ......... 237 G.4 Antenatal prophylactic antibiotics for women with P-PROM ................... 244 G.5 Identifying infection in women with P-PROM .......................................... 248 G.6 ‘Rescue’ cervical cerclage ...................................................................... 253 G.7 Diagnosing preterm labour for women with intact membranes ............... 255 G.8 Maternal corticosteroids ......................................................................... 267 G.9 Magnesium sulphate for neuroprotection ............................................... 271 G.10 Tocolysis ................................................................................................ 277 G.11 Fetal monitoring ..................................................................................... 291 G.12 Mode of birth .......................................................................................... 297 G.13 Timing of cord clamping for preterm babies ........................................... 303 Appendix H Evidence tables .................................................................................... 309 Appendix I Forest plots .......................................................................................... 310 Appendix J Network meta-analysis of tocolytics .................................................. 311 5 PTLB - Appendices Scope Appendices 1 2 Appendix A Scope 3 6 @2015 National Collaborating Centre for Women's and Children's Health PTLB - Appendices Scope 1 7 @2015 National Collaborating Centre for Women's and Children's Health PTLB - Appendices Scope 1 8 @2015 National Collaborating Centre for Women's and Children's Health PTLB - Appendices Scope 1 9 @2015 National Collaborating Centre for Women's and Children's Health PTLB - Appendices Scope 1 10 @2015 National Collaborating Centre for Women's and Children's Health

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